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Article

Quantification of random genomic mutations.

Nature methods - 1 Apr 2005

Bielas Jason H, Loeb Lawrence A

Abstract excerpt

Cancer cells contain numerous clonal mutations. It has been theorized that malignant cells sustain an elevated mutation rate and, as a consequence, harbor yet larger numbers of random point mutations. Testing this hypothesis has been precluded by lack of an assay to measure random mutations-that is, mutations that occur in only one or a few cells of a population. We have established a method that has permitted us...

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PMID: 15782221
DOI: 10.1038/nmeth751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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