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Article

The frequency of granulocytes with spontaneous somatic mutations: a wide distribution in a normal human population.

PloS one - 1 Jan 2013

Rondelli Tommaso, Berardi Margherita, Peruzzi Benedetta, Boni Luca, Caporale Roberto, Dolara Piero, Notaro Rosario, Luzzatto Lucio

Abstract excerpt

Germ-line mutation rate has been regarded classically as a fundamental biological parameter, as it affects the prevalence of genetic disorders and the rate of evolution. Somatic mutation rate is also an important biological parameter, as it may influence the development and/or the course of acquired diseases, particularly of cancer. Estimates of this parameter have been previously obtained in few instances from...

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Identifiers

PMID: 23342069
DOI: 10.1371/journal.pone.0054046
PMCID: PMC3544671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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