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Article

Distinct mechanisms lead to HPRT gene mutations in leukemic cells.

Genes, chromosomes & cancer - 1 Apr 2004

Lin Ying-Wei, Perkins Jonathan J, Zhang Zhenhua, Aplan Peter D

Abstract excerpt

Leukemias are considered malignant clonal disorders arising from the accumulation of mutations in hematopoietic cells; the majority of these mutations are thought to be acquired somatically. Measurement of mutation frequency (Mf) at the hypoxanthine phosphoribosyltransferase (HPRT) locus has been developed as a method for estimating genomic instability. We investigated the Mf in 16 leukemic cell lines to...

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PMID: 14978792
DOI: 10.1002/gcc.20005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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