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Article

Elevated incidence of polyp formation in APC(Min/⁺)Msh2⁻/⁻ mice is independent of nitric oxide-induced DNA mutations.

PloS one - 1 Jan 2013

Belcheva Antoaneta, Green Blerta, Weiss Ashley, Streutker Catherine, Martin Alberto

Abstract excerpt

Gut microbiota has been linked to a number of human diseases including colon cancer. However, the mechanism through which gut bacteria influence colon cancer development and progression remains unclear. Perturbation of the homeostasis between the host immune system and microbiota leads to inflammation and activation of macrophages which produce large amounts of nitric oxide that acts as a genotoxic effector...

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Share to Adenomatous Polyposis Coli Protein
Share to Colonic Polyps

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to Macrophages

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Share to MutS Homolog 2 Protein

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Share to Nitric Oxide Synthase Type II

Source

Open in PubMed Open full text

Identifiers

PMID: 23741483
DOI: 10.1371/journal.pone.0065204
PMCID: PMC3669241

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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