Article
Analysis of mutations in tumor and normal adjacent tissue via fluorescence detection.
Environmental and molecular mutagenesis - 1 Feb 2021
Kay Jennifer E, Mirabal Sheyla, Briley William E, Kimoto Takafumi, Poutahidis Theofilos, Ragan Timothy, So Peter T, Wadduwage Dushan N, Erdman Susan E, Engelward Bevin P
Abstract excerpt
Inflammation is a major risk factor for many types of cancer, including colorectal. There are two fundamentally different mechanisms by which inflammation can contribute to carcinogenesis. First, reactive oxygen and nitrogen species (RONS) can damage DNA to cause mutations that initiate cancer. Second, inflammatory cytokines and chemokines promote proliferation, migration, and invasion. Although it is known that...
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