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Article

Mismatch repair deficient mice show susceptibility to oxidative stress-induced intestinal carcinogenesis.

International journal of biological sciences - 1 Jan 2013

Piao Jingshu, Nakatsu Yoshimichi, Ohno Mizuki, Taguchi Ken-ichi, Tsuzuki Teruhisa

Abstract excerpt

We have previously established an experimental system for oxidative DNA damage-induced tumorigenesis in the small intestine of mice. To elucidate the roles of mismatch repair genes in the tumor suppression, we performed oxidative DNA damage-induced tumorigenesis experiments using Msh2-deficient mice. Oral administration of 0.2% Potassium Bromate, KBrO3, effectively induced epithelial tumors in the small...

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Source

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Identifiers

PMID: 24391453
DOI: 10.7150/ijbs.5750
PMCID: PMC3879593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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