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Article

DNA repair is indispensable for survival after acute inflammation.

The Journal of clinical investigation - 1 Jul 2012

Calvo Jennifer A, Meira Lisiane B, Lee Chun-Yue I, Moroski-Erkul Catherine A, Abolhassani Nona, Taghizadeh Koli, Eichinger Lindsey W, Muthupalani Sureshkumar, Nordstrand Line M, Klungland Arne, Samson Leona D

Abstract excerpt

More than 15% of cancer deaths worldwide are associated with underlying infections or inflammatory conditions, therefore understanding how inflammation contributes to cancer etiology is important for both cancer prevention and treatment. Inflamed tissues are known to harbor elevated etheno-base (ε-base) DNA lesions induced by the lipid peroxidation that is stimulated by reactive oxygen and nitrogen species (RONS)...

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Identifiers

PMID: 22684101
DOI: 10.1172/JCI63338
PMCID: PMC3386829

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ALKBH2
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