Article
Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors.
Cancer research - 1 Apr 2002
Kohonen-Corish Maija R J, Daniel Joseph J, te Riele Hein, Buffinton Gary D, Dahlstrom Jane E
Abstract excerpt
Patients with longstanding extensive ulcerative colitis have an increased risk of developing colorectal cancer (CRC). There are significant differences in the early pathogenesis of colitis-associated tumors compared with common CRC, whereas the frequency, degree, and significance of microsatellite instability (MSI) as a marker of mismatch repair deficiency in colitis tumors remain unclear. Here we describe the...
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