Article
Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease.
Environmental and molecular mutagenesis - 1 Jan 2004
Goodman Julie E, Hofseth Lorne J, Hussain S Perwez, Harris Curtis C
Abstract excerpt
Nitric oxide (NO(.)), which is generated under chronic inflammatory conditions that predispose individuals to cancer, has paradoxical effects. NO(.) can activate p53, which can result in anti-carcinogenic effects, or it can be mutagenic and increase cancer risk. We explored the mechanisms by which NO(.) induced p53 activation in vitro and found that NO(.) induced p53 accumulation and phosphorylation, particularly...
Topics
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle
- Cell Cycle Proteins
- Colitis, Ulcerative
- Colonic Neoplasms
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA-Binding Proteins
- Humans
- Mutation
- Nitric Oxide
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Nuclear Proteins