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Article

Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease.

Environmental and molecular mutagenesis - 1 Jan 2004

Goodman Julie E, Hofseth Lorne J, Hussain S Perwez, Harris Curtis C

Abstract excerpt

Nitric oxide (NO(.)), which is generated under chronic inflammatory conditions that predispose individuals to cancer, has paradoxical effects. NO(.) can activate p53, which can result in anti-carcinogenic effects, or it can be mutagenic and increase cancer risk. We explored the mechanisms by which NO(.) induced p53 activation in vitro and found that NO(.) induced p53 accumulation and phosphorylation, particularly...

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PMID: 15199542
DOI: 10.1002/em.20024

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