Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer.

Nature communications - 14 Apr 2020

Irrazabal Thergiory, Thakur Bhupesh K, Kang Mingsong, Malaise Yann, Streutker Catherine, Wong Erin O Y, Copeland Julia, Gryfe Robert, Guttman David S, Navarre William W, Martin Alberto

Abstract excerpt

Inflammatory bowel disease patients have a greatly increased risk of developing colitis-associated colon cancer (CAC); however, the basis for inflammation-induced genetic damage requisite for neoplasia is unclear. Using three models of CAC, we find that sustained inflammation triggers 8-oxoguanine DNA lesions. Strikingly, antioxidants or iNOS inhibitors reduce 8-oxoguanine and polyps in CAC models. Because the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Colitis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Dextran Sulfate

Share to Dysbiosis

Share to Guanosine

Share to Helicobacter Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 32286276
DOI: 10.1038/s41467-020-15549-6
PMCID: PMC7156452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer.PMID 32286276Read ↗

Mismatch Repair and Colon Cancer: Mechanisms and Therapies Explored.Semantic proximity Read ↗

DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice.Semantic proximity Read ↗

Molecular Aspects of Colorectal Adenomas: The Interplay among Microenvironment, Oxidative Stress, and Predisposition.Semantic proximity Read ↗

Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer.Semantic proximity Read ↗

DNA repair is indispensable for survival after acute inflammation.Semantic proximity Read ↗

Xanthine oxidoreductase promotes the progression of colitis-associated colorectal cancer by causing DNA damage and mediating macrophage M1 polarizationSemantic proximity Read ↗

Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis.Semantic proximity Read ↗

Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammationSemantic proximity Read ↗

Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancerSemantic proximity Read ↗

Oxidative stress in ulcerative colitis: an old concept but a new concernSemantic proximity Read ↗

DNA glycosylase NEIL2 prevents <i>Fusobacterium</i> -mediated inflammation and DNA damage in colonic epithelial cellsSemantic proximity Read ↗

Colorectal cancer: role of commensal bacteria and bystander effectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.