Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jun 2013

Kampmann Martin, Bassik Michael C, Weissman Jonathan S

Abstract excerpt

A major challenge of the postgenomic era is to understand how human genes function together in normal and disease states. In microorganisms, high-density genetic interaction (GI) maps are a powerful tool to elucidate gene functions and pathways. We have developed an integrated methodology based o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Epistasis, Genetic
Share to Genomic Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to K562 Cells

Share to Lymphoma

Share to Mammals

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 23739767
DOI: 10.1073/pnas.1307002110
PMCID: PMC3690882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23739767-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells.PMID 23739767Read ↗

A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of conceptSemantic proximity Read ↗

Measuring genetic interactions in human cells by RNAi and imaging.Semantic proximity Read ↗

Profiling essential genes in human mammary cells by multiplex RNAi screening.Semantic proximity Read ↗

Using pooled miR30-shRNA library for cancer lethal and synthetic lethal screens.Semantic proximity Read ↗

Scaling perturbations: beyond genome-scale CRISPR screensSemantic proximity Read ↗

Pooled PPIseq: screening the SARS-CoV-2 and human interface with a scalable multiplexed protein-protein interaction assay platformSemantic proximity Read ↗

Dissecting Molecular Phenotypes Through FACS-Based Pooled CRISPR Screens.Semantic proximity Read ↗

Cellular phenotyping by RNAi.Semantic proximity Read ↗

Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.Semantic proximity Read ↗

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing.Semantic proximity Read ↗

Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cellsSemantic proximity Read ↗

Optimization of molecular tools for high-throughput genetic screeningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.