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Article

Profiling essential genes in human mammary cells by multiplex RNAi screening.

Science (New York, N.Y.) - 1 Feb 2008

Silva Jose M, Marran Krista, Parker Joel S, Silva Javier, Golding Michael, Schlabach Michael R, Elledge Stephen J, Hannon Gregory J, Chang Kenneth

Abstract excerpt

By virtue of their accumulated genetic alterations, tumor cells may acquire vulnerabilities that create opportunities for therapeutic intervention. We have devised a massively parallel strategy for screening short hairpin RNA (shRNA) collections for stable loss-of-function phenotypes. We assayed from 6000 to 20,000 shRNAs simultaneously to identify genes important for the proliferation and survival of five cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18239125
DOI: 10.1126/science.1149185
PMCID: PMC2981861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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