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Article

Astrocytes expressing mutant hnRNPA1 induce non-cell-autonomous motor neuron death.

Brain research bulletin - 1 Oct 2025

Wu Qinxue, Liu Xionghao, Zhang Tingting, Cui Shiquan, Huang Bo, Huang Cao, Cao Qilin, Xia Xu-Gang, Zhou Hongxia

Abstract excerpt

Pathogenic mutation of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is causative to amyotrophic lateral sclerosis (ALS). Neuron death resulting from pathogenic hnRNPA1 may not require its presence across all pertinent cells types, including neurons, glia, and muscles. Rather, the exclusive presence of pathogenic hnRNPA1 in a specific cell type, such as astrocytes, may suffice to substantially alter...

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Identifiers

PMID: 40858193
DOI: 10.1016/j.brainresbull.2025.111522
PMCID: PMC13392966

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