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Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS.

Neurochemical research - 1 Jun 2020

Barton Samantha K, Lau Chew L, Chiam Mathew D F, Tomas Doris, Muyderman Hakan, Beart Philip M, Turner Bradley J

Abstract excerpt

Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase 1 (SOD1) is partly non-cell autonomous, involving cellular dysfunction of astrocytes. Whether non-cell autonomous effects occur in other forms of ALS, such as TAR DNA binding protein 43 (TDP-43)-related disease, remains unclear. Here, we characterised the impact of mutant TDP-43 expression on primary...

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PMID: 32410044
DOI: 10.1007/s11064-020-03048-5

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