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Article

Significance of aberrant glial cell phenotypes in pathophysiology of amyotrophic lateral sclerosis.

Neuroscience letters - 1 Jan 2017

Trias Emiliano, Ibarburu Sofia, Barreto-Núñez Romina, Barbeito Luis

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a paradigmatic neurodegenerative disease, characterized by progressive paralysis of skeletal muscles associated with motor neuron degeneration. It is well-established that glial cells play a key role in ALS pathogenesis. In transgenic rodent models for familial ALS reactive astrocytes, microglia and oligodendrocyte precursors accumulate in the degenerating spinal cord and...

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PMID: 27473942
DOI: 10.1016/j.neulet.2016.07.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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