Article
Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.
Proceedings of the National Academy of Sciences of the United States of America - 17 Nov 2020
Peng Audrey Yi Tyan, Agrawal Ira, Ho Wan Yun, Yen Yi-Chun, Pinter Ashley J, Liu Jerry, Phua Qi Xuan Cheryl, Koh Katrianne Bethia, Chang Jer-Cherng, Sanford Emma, Man Jodie Hon Kiu, Wong Peiyan, Gutmann David H, Tucker-Kellogg Greg, Ling Shuo-Chien
Abstract excerpt
Patients with amyotrophic lateral sclerosis (ALS) can have abnormal TDP-43 aggregates in the nucleus and cytosol of their surviving neurons and glia. Although accumulating evidence indicates that astroglial dysfunction contributes to motor neuron degeneration in ALS, the normal function of TDP-43 in astrocytes are largely unknown, and the role of astroglial TDP-43 loss to ALS pathobiology remains to be clarified....
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