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Glial Cell Dysfunction in C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Cells - 28 Jan 2021

Ghasemi Mehdi, Keyhanian Kiandokht, Douthwright Catherine

Abstract excerpt

Since the discovery of the chromosome 9 open reading frame 72 (C9orf72) repeat expansion mutation in 2011 as the most common genetic abnormality in amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) and frontotemporal dementia (FTD), progress in understanding the signaling pathways related to this mutation can only be described as intriguing. Two major theories have been suggested-(i) loss of...

Topics

Amyotrophic Lateral Sclerosis
C9orf72 Protein
Frontotemporal Dementia
Humans
Inflammation
Mutation
Neuroglia

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33525344
DOI: 10.3390/cells10020249
PMCID: PMC7912327

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