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Article

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.

Acta neuropathologica communications - 25 Jun 2015

Mitchell Jacqueline C, Constable Remy, So Eva, Vance Caroline, Scotter Emma, Glover Leanne, Hortobagyi Tibor, Arnold Eveline S, Ling Shuo-Chien, McAlonis Melissa, Da Cruz Sandrine, Polymenidou Magda, Tessarolo Lino, Cleveland Don W, Shaw Christopher E

Abstract excerpt

INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disorder, and cytoplasmic inclusions containing transactive response (TAR) DNA binding protein (TDP-43) are present in ~90 % of cases. Here we report detailed pathology in human TDP-43 transgenic mice that recapitulate key features of TDP-43-linked ALS. RESULTS: Expression of human wild-type TDP-43 (TDP-43(WT))...

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Identifiers

PMID: 26108367
DOI: 10.1186/s40478-015-0212-4
PMCID: PMC4479086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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