Article
Maternal genotype influences behavioral development of 3×Tg-AD mouse pups.
Behavioural brain research - 1 Sept 2013
Blaney Caitlin E, Gunn Rhian K, Stover Kurt R, Brown Richard E
Abstract excerpt
Transgenic mice are a valuable tool in the investigation of neurodegenerative disorders such as Alzheimer's disease. The triple transgenic mouse (3×Tg-AD) is a model of Alzheimer's disease that possesses age-related amyloid beta plaques, neurofibrillary tangles and cell death as well as cognitive decline. Because maternal effects may interact with pup genotype in determining behavior phenotypes, we used a...
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