Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Limited impact of social isolation on Alzheimer-like symptoms in a triple transgenic mouse model.

Behavioral neuroscience - 1 Feb 2009

Pietropaolo Susanna, Sun Yan, Li Ruixi, Brana Corinne, Feldon Joram, Yee Benjamin K

Abstract excerpt

Gene-environment interactions are known to play a major role in the ethiopathology of several neuropsychiatric disorders, including Alzheimer's disease (AD). The present study investigates whether environmental manipulations, that is, social isolation, may affect the genetic predisposition to develop AD-related traits in a triple transgenic mouse model (3 x Tg-AD), as suggested by our previous study employing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acoustic Stimulation
Share to Cues
Share to Exploratory Behavior

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Maze Learning

Share to Reflex, Startle

Share to Schizophrenic Psychology

Share to Social Isolation

Share to Space Perception

Source

Identifiers

PMID: 19170443
DOI: 10.1037/a0013607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Limited impact of social isolation on Alzheimer-like symptoms in a triple transgenic mouse model.PMID 19170443Read ↗

Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice.Semantic proximity Read ↗

Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1 MiceSemantic proximity Read ↗

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.Semantic proximity Read ↗

Chronic social isolation-unpredictable stress induces early-onset cognitive deficits and exacerbates Aβ accumulation in the 5xFAD mouse model of Alzheimer's disease.Semantic proximity Read ↗

Isolation housing exacerbates Alzheimer’s Disease phenotype in aged APP KI miceSemantic proximity Read ↗

Prolonged isolation stress accelerates the onset of Alzheimer’s disease-related pathology in 5xFAD mice despite running wheels and environmental enrichmentSemantic proximity Read ↗

The Involvement of Cdk5 Activator p35 in Social Isolation-Triggered Onset of Early Alzheimer’s Disease-Related Cognitive Deficit in the Transgenic MiceSemantic proximity Read ↗

Sex differences in behaviour and molecular pathology in the 5XFAD modelSemantic proximity Read ↗

Sex Differences in Behavior and Molecular Pathology in the 5XFAD Model.Semantic proximity Read ↗

Early Amyloid-β Deposits and Astrogliosis Are Modulated by Housing Conditions in 5xFAD MiceSemantic proximity Read ↗

Social Interaction Deficits Emerge Alongside Anxiety-Like Behavior in TgF344-AD RatsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.