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Article

Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure.

Brain research - 17 Dec 2010

Carroll Jenna C, Rosario Emily R, Kreimer Sara, Villamagna Angela, Gentzschein Elisabet, Stanczyk Frank Z, Pike Christian J

Abstract excerpt

The risk of Alzheimer's disease (AD) is higher in women than in men, a sex difference that likely results from the effects of sex steroid hormones. To investigate this relationship, we first compared progression of β-amyloid (Aβ) pathology in male and female triple transgenic (3xTg-AD) mice. We found that female 3xTg-AD mice exhibit significantly greater Aβ burden and larger behavioral deficits than age-matched...

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Identifiers

PMID: 20934413
DOI: 10.1016/j.brainres.2010.10.009
PMCID: PMC2993873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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