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Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult

18 Jun 2012

Abstract excerpt

BACKGROUND: Transgenic mice expressing disease-associated proteins have become standard tools for studying human neurological disorders. Transgenes are often expressed using promoters chosen to drive continuous high-level expression throughout life rather than temporal and spatial fidelity to the endogenous gene. This approach has allowed us to recapitulate diseases of aging within the two-year lifespan of the...

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PMID: 22709352
DOI: 10.1186/1750-1326-7-28

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