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Article

Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice.

Autism research : official journal of the International Society for Autism Research - 1 Jun 2008

Chadman Kathryn K, Gong Shiaoching, Scattoni Maria L, Boltuck Sarah E, Gandhy Shruti U, Heintz Nathaniel, Crawley Jacqueline N

Abstract excerpt

Neuroligin-3 is a member of the class of cell adhesion proteins that mediate synapse development and have been implicated in autism. Mice with the human R451C mutation (NL3), identical to the point mutation found in two brothers with autism spectrum disorders, were generated and phenotyped in multiple behavioral assays with face validity to the diagnostic symptoms of autism. No differences between NL3 and their...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19360662
DOI: 10.1002/aur.22
PMCID: PMC2701211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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