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Article

Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.

Disease models & mechanisms - 1 Aug 2025

Boyanova Sevda, Banks Gareth, Lipina Tatiana V, Bains Rasneer Sonia, Forrest Hamish, Stewart Michelle, Carcolé Mireia, Milioto Carmelo, Isaacs Adrian M, Wells Sara E, Wiseman Frances K

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive adult-onset neurodegenerative diseases with overlapping pathological and genetic origins. They are caused by multiple underlying mechanisms leading to a common collection of clinical features that occur in a spectrum. Here, we report side-by-side longitudinal behavioural, cognitive and sensory phenotyping of two mouse models of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40856010
DOI: 10.1242/dmm.052324
PMCID: PMC12421800

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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