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Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD).

Behavioural brain research - 1 Oct 2012

Filali Mohammed, Lalonde Robert, Theriault Peter, Julien Carl, Calon Frederic, Planel Emmanuel

Abstract excerpt

3xTg-AD mutant mice are characterized by parenchymal Aβ plaques and neurofibrillary tangles resembling those found in patients with Alzheimer's disease. The mutants were compared with non-transgenic controls in sensorimotor and learning tests. 3xTg-AD mutants were deficient in T-maze reversal, object recognition, and passive avoidance learning. In addition, the mutants showed hypoactivity in two open-field tests,...

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Source

Identifiers

PMID: 22796601
DOI: 10.1016/j.bbr.2012.07.004

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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