Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.

Behavioral neuroscience - 1 Aug 2008

Pietropaolo Susanna, Feldon Joram, Yee Benjamin K

Abstract excerpt

The triple-transgenic mouse line (3 x Tg-AD) harboring PS1M146V, APPSwe, and taup301L transgenes represents the only transgenic model for Alzheimer's disease (AD) to date capturing both beta-amyloid and tau neuropathology. The present study provides an extensive behavioral characterization of the 3 x Tg-AD mouse line, evaluating the emergence of noncognitive and cognitive AD-like symptoms at two ages...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acoustic Stimulation
Share to Amyloid beta-Protein Precursor
Share to Avoidance Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Classical

Share to Maze Learning

Share to Presenilin-1

Share to Psychomotor Performance

Share to Reflex, Startle

Source

Identifiers

PMID: 18729626
DOI: 10.1037/a0012520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.PMID 18729626Read ↗

The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 × Tg-AD) mouse model strainSemantic proximity Read ↗

Age and gender differences for the behavioral phenotypes of 3xTg alzheimer's disease mice.Semantic proximity Read ↗

Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD).Semantic proximity Read ↗

Transgenic mouse models of Alzheimer's disease: phenotype and application.Semantic proximity Read ↗

Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease.Semantic proximity Read ↗

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.Semantic proximity Read ↗

Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Early-in-life neuroanatomical and behavioural trajectories in a triple transgenic model of Alzheimer's disease.Semantic proximity Read ↗

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.Semantic proximity Read ↗

Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease ResearchSemantic proximity Read ↗

APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.