Article
Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen.
Behavioural brain research - 10 Feb 2005
Lalonde R, Dumont M, Staufenbiel M, Strazielle C
Abstract excerpt
The SHIRPA primary screen comprises 40 measures covering various reflexes and basic sensorimotor functions. This multi-test battery was used to compare non-transgenic controls with APP23 transgenic mice, expressing the 751 isoform of human beta-amyloid precursor protein and characterized by amyloid deposits in parenchyma and vessel walls. The APP23 mice were distinguishable from controls by pathological limb...
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