Article
Dynamic methylation of Numb by Set8 regulates its binding to p53 and apoptosis.
Molecular cell - 23 May 2013
Dhami Gurpreet Kaur, Liu Huadong, Galka Marek, Voss Courtney, Wei Ran, Muranko Kimberly, Kaneko Tomonori, Cregan Sean P, Li Lin, Li Shawn Shun-Cheng
Abstract excerpt
Although Numb exhibits its tumor-suppressive function in breast cancer in part by binding to and stabilizing p53, it is unknown how the Numb-p53 interaction is regulated in cells. We found that Numb is methylated in its phosphotyrosine-binding (PTB) domain by the lysine methyltransferase Set8. Moreover, methylation uncouples Numb from p53, resulting in increased p53 ubiquitination and degradation. While Numb...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.