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Article

The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair

18 Feb 2019

Abstract excerpt

P53-binding protein 1 (53BP1) mediates DNA repair pathway choice and promotes checkpoint activation. Chromatin marks induced by DNA double-strand breaks and recognized by 53BP1 enable focal accumulation of this multifunctional repair factor at damaged chromatin. Here, we unveil an additional level of regulation of 53BP1 outside repair foci. 53BP1 movements are constrained throughout the nucleoplasm and increase...

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PMID: 30812030
DOI: 10.1093/nar/gkz138

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