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Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool

6 Oct 2022

Abstract excerpt

Asymmetric cell division is a key tumor suppressor mechanism that prevents the uncontrolled expansion of the stem cell (SC) compartment by generating daughter cells with alternative fates: one retains SC identity and enters quiescence and the other becomes a rapidly proliferating and differentiating progenitor. A critical player in this process is Numb, which partitions asymmetrically at SC mitosis and inflicts...

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Identifiers

PMID: 36200956
DOI: 10.1083/jcb.202112001

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Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell poolPMID 36200956Read ↗

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