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Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene.

Toxicologic pathology - 1 Jan 2014

Bhusari Sachin, Malarkey David E, Hong Hue-Hua, Wang Yu, Masinde Tiwanda, Nolan Michael, Hooth Michelle J, Lea Isabel A, Vasconcelos Daphne, Sills Robert C, Hoenerhoff Mark J

Abstract excerpt

3,3',4,4'-tetrachloroazobenzene (TCAB) is a contaminant formed during manufacture of various herbicide compounds. A recent National Toxicology Program study showed B6C3F1 mice exposed to TCAB developed a treatment-related increase in lung carcinomas in the high-dose group, and urethral carcinomas, an extremely rare lesion in rodents, in all dose groups. As the potential for environmental exposure to TCAB is...

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PMID: 23703846
DOI: 10.1177/0192623313491169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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