Induction of thioguanine-resistant mutations in human uroepithelial cells by 4-aminobiphenyl and its N-hydroxy derivatives.

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Article

Induction of thioguanine-resistant mutations in human uroepithelial cells by 4-aminobiphenyl and its N-hydroxy derivatives.

Cancer research - 15 Mar 1992

Bookland E A, Reznikoff C A, Lindstrom M, Swaminathan S

Abstract excerpt

The mutagenic potentials of the human bladder carcinogen 4-amino-biphenyl (ABP) and three of its proximate carcinogenic metabolites, N-hydroxy-4-aminobiphenyl (N-OH-ABP), N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) and N-acetoxy-4-acetylaminobiphenyl (N-OAc-AABP) were tested on a prime human targ...

Topics

Aminobiphenyl Compounds
Cell Line, Transformed
Dimethyl Sulfoxide
Drug Resistance
Humans
Hypoxanthine Phosphoribosyltransferase
Methylnitronitrosoguanidine
Mutation
Simian virus 40
Thioguanine
Urinary Bladder Neoplasms

Source

Open in PubMed

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PMID: 1311636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1311636-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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