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Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal.

Toxicologic pathology - 1 Aug 2015

Hong Hue-Hua L, Hoenerhoff Mark J, Ton Thai-Vu, Herbert Ronald A, Kissling Grace E, Hooth Michelle J, Behl Mamta, Witt Kristine L, Smith-Roe Stephanie L, Sills Robert C, Pandiri Arun R

Abstract excerpt

Rodent lung tumors are morphologically similar to a subtype of human lung adenocarcinomas. The objective of this study was to evaluate Kirsten rat sarcoma oncogene homolog (Kras), epidermal growth factor receptor (Egfr), and tumor protein 53 (Tp53) mutations, which are relevant to human lung cancer, in cobalt metal dust (CMD)-induced alveolar/bronchiolar tumors of B6C3F1/N mice and F344/NTac rats. Kras mutations...

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Identifiers

PMID: 26059825
DOI: 10.1177/0192623315581192
PMCID: PMC4526332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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