Article
Benzo[b]fluoranthene Induces Mutation Accumulation and Cancer-Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood.
Environmental and molecular mutagenesis - 1 Jun 2026
Zhang Xinwen, Hobbs Cheryl A, Rivas Miriam V, Diesing Alex, LeBlanc Danielle P M, Zhou Gu, Foley Julie F, White Paul A, Marchetti Francesco, Yauk Carole L, Smith-Roe Stephanie L
Abstract excerpt
Polycyclic aromatic hydrocarbons (PAHs) are well-known for their mutagenic and carcinogenic effects. Benzo[b]fluoranthene (BbF) is one of 16 PAHs prioritized by the US Environmental Protection Agency for toxicological evaluation due to pervasive human exposure. As part of a multi-stakeholder consortium, the genotoxic effects of BbF were evaluated in MutaMouse males exposed to five doses of BbF or a vehicle...
Topics
- Animals
- Male
- Lung
- Mice
- Fluorenes
- Micronucleus Tests
- Mutation
- Mutagens
- Chromosome Aberrations
- DNA Damage
- Mutagenesis
- Lung Neoplasms