K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.

doi:10.1080/01926230601063839

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.

Toxicologic pathology - 1 Jan 2007

Hong Hue-Hua L, Houle Christopher D, Ton Thai-Vu T, Sills Robert C

Abstract excerpt

Ethylene oxide is a multisite carcinogen in rodents and classified as a human carcinogen by the National Toxicology Program. In 2-year mouse studies, ethylene oxide (EO) induced lung, Harderian gland (HG), and uterine neoplasms. We evaluated representative EO-induced and equivalent spontaneous neoplasms for K-ras mutations in codons 12, 13, and 61. K-ras mutations were identified in 100% (23/23) of the EO-induced...

Topics

Adenocarcinoma
Adenoma
Animals
Carcinogens
DNA, Neoplasm
Disinfectants
Dose-Response Relationship, Drug
Ethylene Oxide
Female
Genes, ras
Harderian Gland

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inhalation Exposure

Lung Neoplasms

Male

Mice

Mice, Inbred Strains

Mutation

Sebaceous Gland Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 17325976
DOI: 10.1080/01926230601063839
PMCID: PMC2099306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.PMID 17325976Read ↗

Temporal changes in K-ras mutant fraction in lung tissue of big blue B6C3F₁ mice exposed to ethylene oxide.Semantic proximity Read ↗

Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice.Semantic proximity Read ↗

Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.Semantic proximity Read ↗

A Review of the Molecular Mechanisms of Chemically Induced Neoplasia in Rat and Mouse Models in National Toxicology Program Bioassays and Their Relevance to Human CancerSemantic proximity Read ↗

Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.Semantic proximity Read ↗

K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation.Semantic proximity Read ↗

Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.Semantic proximity Read ↗

In vivo mutagenicity and mutation spectrum in the bone marrow and testes of B6C3F1 lacI transgenic mice following inhalation exposure to ethylene oxide.Semantic proximity Read ↗

Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months.Semantic proximity Read ↗

Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide.Semantic proximity Read ↗

Assessment of the in vivo mutagenicity of ethylene oxide in the tissues of B6C3F1 lacI transgenic mice following inhalation exposure.Semantic proximity Read ↗

Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.