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Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation.

Toxicologic pathology - 1 Jan 2016

Hayes Schantel A, Pandiri Arun R, Ton Thai-vu T, Hong Hue-Hua L, Clayton Natasha P, Shockley Keith R, Peddada Shyamal D, Gerrish Kevin, Wyde Michael, Sills Robert C, Hoenerhoff Mark J

Abstract excerpt

Vinylidene chloride (VDC) has been widely used in the production of plastics and flame retardants. Exposure of B6C3F1 mice to VDC in the 2-year National Toxicology Program carcinogenicity bioassay resulted in a dose-dependent increases in renal cell hyperplasia, renal cell adenoma, and renal cell carcinomas (RCCs). Among those differentially expressed genes from controls and RCC of VDC-exposed mice, there was an...

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Identifiers

PMID: 26682919
DOI: 10.1177/0192623315610820
PMCID: PMC4752433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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