Article
Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2'-dimethyl-4-aminobiphenyl.
Molecular carcinogenesis - 1 May 1995
Masui T, Shirai T, Imaida K, Hirose M, Futakuchi M, Tatematsu M, Ito N
Abstract excerpt
We have developed a prostate carcinogenesis model in Fischer 344 rats using 3,2'-dimethyl-4-aminobiphenyl (DMAB) as a carcinogen to examine various potential modifying factors. In this study, mutational changes in the ras and p53 genes were assessed in DMAB-induced rat prostate and seminal vesicl...
Topics
- Adenocarcinoma
- Alleles
- Aminobiphenyl Compounds
- Animals
- Base Sequence
- Gene Deletion
- Genes, p53
- Genes, ras
- Genital Neoplasms, Male
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Prostatic Neoplasms
- Rats
- Rats, Inbred F344
- Seminal Vesicles