Polymorphism in drug transporter gene ABCB1 is associated with drug resistance in Pakistani epilepsy patients.

doi:10.1016/j.eplepsyres.2021.106814

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Polymorphism in drug transporter gene ABCB1 is associated with drug resistance in Pakistani epilepsy patients.

Epilepsy research - 1 Dec 2021

Maqbool Hafsa, Saleem Tayyaba, Sheikh Nadeem, Asmatullah, Mukhtar Maryam, Javed Iram, Rehman Atia

Abstract excerpt

Despite the best possible medication and treatment protocols, one-third of epilepsy patients have drug resistance which is associated with an elevated risk of mortality and debilitating psychological consequences. P-glycogen encoded by ABCB1 is major drug transporter for a wide variety of AED. To evaluate the complex haplotypic association, genetic and allelic frequency distribution of rs1128503, rs1045642, and...

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PMID: 34844091
DOI: 10.1016/j.eplepsyres.2021.106814

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