Article
Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy.
Pharmacogenetics and genomics - 1 Oct 2011
Ufer Mike, von Stülpnagel Celina, Muhle Hiltrud, Haenisch Sierk, Remmler Cornelia, Majed Amani, Plischke Herbert, Stephani Ulrich, Kluger Gerhard, Cascorbi Ingolf
Abstract excerpt
BACKGROUND: Antiepileptic treatment response has been suggested to be modulated by genetic polymorphisms of drug efflux transporters, in particular ABCB1. Recently, we found a significant association of ABCC2 -24C>T with nonresponse, primarily in the context of generalized epilepsy. Moreover, ABCC2 1249G>A was reported to alter transmembranal carbamazepine transport. Therefore, we aimed to confirm the association...
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