Article
FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer.
PloS one - 1 Jan 2013
Peláez-García Alberto, Barderas Rodrigo, Torres Sofía, Hernández-Varas Pablo, Teixidó Joaquín, Bonilla Félix, de Herreros Antonio Garcia, Casal J Ignacio
Abstract excerpt
Fibroblast growth factor receptor 4 (FGFR4) is vital in early development and tissue repair. FGFR4 expression levels are very restricted in adult tissues, except in several solid tumors including colorectal cancer, which showed overexpression of FGFR4. Here, FGFR4 mutation analysis discarded the presence of activating mutations, other than Arg(388), in different colorectal cancer cell lines and tumoral samples....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.