Differential effects of polymorphic alleles of FGF receptor 4 on colon cancer growth and metastasis.

doi:10.1158/0008-5472.CAN-11-3654

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Article

Differential effects of polymorphic alleles of FGF receptor 4 on colon cancer growth and metastasis.

Cancer research - 15 Nov 2012

Heinzle Christine, Gsur Andrea, Hunjadi Monika, Erdem Zeynep, Gauglhofer Christine, Stättner Stefan, Karner Josef, Klimpfinger Martin, Wrba Friedrich, Reti Andrea, Hegedus Balazs, Baierl Andreas, Grasl-Kraupp Bettina, Holzmann Klaus, Grusch Michael, Berger Walter, Marian Brigitte

Abstract excerpt

A gly(388)arg polymorphism (rs351855) in the transmembrane domain of the fibroblast growth factor receptor (FGFR4) is associated with increased risk, staging, and metastasis in several different types of cancer. To specifically assess the impact of the polymorphic FGFR4 in colorectal cancer (CRC), we engineered CRC cell lines with distinct endogenous expression patterns to overexpress either the FGFR4(gly) or...

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Identifiers

PMID: 22971346
DOI: 10.1158/0008-5472.CAN-11-3654
PMCID: PMC5455878

Genes

FGFR4

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