Article
Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention.
Journal of hepatology - 1 Jan 2009
Ho Han Kiat, Pok Sharon, Streit Sylvia, Ruhe Jens E, Hart Stefan, Lim Kah Suan, Loo Hooi Linn, Aung Myat Oo, Lim Seng Gee, Ullrich Axel
Abstract excerpt
BACKGROUND/AIMS: FGFR4, a member of the fibroblast growth factor receptor family, has been recently associated with progression of melanoma, breast and head and neck carcinoma. Given its uniquely high expression in the liver, we investigated its contributory role to hepatocellular carcinoma (HCC). METHODS: We performed a comprehensive sequencing of full-length FGFR4 transcript in 57 tumor/normal HCC tissue pairs,...
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