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Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

26 Apr 2021

Abstract excerpt

Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abnormal FGFR4 production explains these cancer formations, and therefore, this receptor has emerged as a potential...

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PMID: 33981224
DOI: 10.3389/fphar.2021.633453

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