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Article

The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction.

Scientific reports - 5 Feb 2018

Quintanal-Villalonga Álvaro, Ojeda-Márquez Laura, Marrugal Ángela, Yagüe Patricia, Ponce-Aix Santiago, Salinas Ana, Carnero Amancio, Ferrer Irene, Molina-Pinelo Sonia, Paz-Ares Luis

Abstract excerpt

The FGFR4-388Arg variant has been related to poor prognosis in several types of cancer, including lung cancer. The mechanism underlying this association has not been addressed in detail in patients with this pathology. Here, we report that this FGFR4 variant induces MAPK and STAT3 activation and causes pro-oncogenic effects in NSCLC in vitro and in vivo. This variant induces the expression of EMT-related genes,...

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Share to Epithelial-Mesenchymal Transition
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinases

Share to Receptor, Fibroblast Growth Factor, Type 4

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Source

Open in PubMed Open full text

Identifiers

PMID: 29402970
DOI: 10.1038/s41598-018-20570-3
PMCID: PMC5799167

Genes

FGFR4
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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