Molecular Targeting of the Fibroblast Growth Factor Receptor (FGFR) Pathway Across Various Cancers

Abstract excerpt

Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases that involve in regulation of cell proliferation, survival, and development. FGFR alterations including amplifications, fusions, rearrangements, and mutations can result downstream activation of tyrosine kinases leading to tumor development. Targeting those FGFR alterations has shown to be effective in cholangiocarcinoma, urotheli...

Topics

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• Drug Resistance, Neoplasm
• Fibroblast Growth Factors
• Gene Fusion
• Molecular Targeted Therapy
• Neoplasms
• Protein Kinase Inhibitors
• Receptors, Fibroblast Growth Factor
• Signal Transduction

Identifiers and source

Literature Corpus work

8b37fb20-5acb-514d-9b6b-6754c7fb928c

DOI

10.20944/preprints202312.0394.v1