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Article

Selective roles of normal and mutant huntingtin in neural induction and early neurogenesis.

PloS one - 1 Jan 2013

Nguyen Giang D, Gokhan Solen, Molero Aldrin E, Mehler Mark F

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by abnormal polyglutamine expansion in the amino-terminal end of the huntingtin protein (Htt) and characterized by progressive striatal and cortical pathology. Previous reports have shown that Htt is essential for embryogenesis, and a recent study by our group revealed that the pathogenic form of Htt (mHtt) causes impairments in multiple stages of...

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Identifiers

PMID: 23691206
DOI: 10.1371/journal.pone.0064368
PMCID: PMC3653864

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EGF
FGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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