Article
<i>In vivo</i> progressive degeneration of Huntington’s disease patient-derived neurons reveals human-specific pathological phenotypes
2020-10-25
Abstract excerpt
Research on neurodegenerative disorders has been hampered by the limited access to patients’ brain tissue and the absence of relevant physiological models with human neurons, accounting for the little success of clinical trials. Moreover, post-mortem samples cannot provide a detailed picture of the complex pathological mechanisms taking place throughout the course of the disease. This holds particularly true for H...
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Identifiers and source
- Literature Corpus work
- df87f6c1-07b4-5564-9351-70826db64675
- DOI
- 10.1101/2020.10.21.347062