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Intervention of Proliferation and Differentiation of Endogenous Neural Stem Cells in the Neurodegenerative Process of Huntington's Disease Phenotype.

CNS & neurological disorders drug targets - 1 Jun 2011

Mazurová Yvona, Gunčová Ivana, Látr Ivan, Rudolf Emil

Abstract excerpt

The evidence for the existence of neurogenesis in the adult mammalian brain, including humans is now widely accepted. Despite the fact that adult neural stem cells appear to be very promising, a wide range of their unrevealed properties, abilities but also limitations under physiological and especially pathological conditions still need to be investigated and explained. Huntington's disease (HD) is characterized...

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PMID: 21495959
DOI: 10.2174/187152711795563967

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