Article
Multiple phenotypes in Huntington disease mouse neural stem cells.
Molecular and cellular neurosciences - 1 May 2012
Ritch James J, Valencia Antonio, Alexander Jonathan, Sapp Ellen, Gatune Leah, Sangrey Gavin R, Sinha Saurabh, Scherber Cally M, Zeitlin Scott, Sadri-Vakili Ghazaleh, Irimia Daniel, Difiglia Marian, Kegel Kimberly B
Abstract excerpt
Neural stem (NS) cells are a limitless resource, and thus superior to primary neurons for drug discovery provided they exhibit appropriate disease phenotypes. Here we established NS cells for cellular studies of Huntington's disease (HD). HD is a heritable neurodegenerative disease caused by a mutation resulting in an increased number of glutamines (Q) within a polyglutamine tract in Huntingtin (Htt). NS cells...
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