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Article

Chromosomal instability during neurogenesis in Huntington's disease.

Development (Cambridge, England) - 29 Jan 2018

Ruzo Albert, Croft Gist F, Metzger Jakob J, Galgoczi Szilvia, Gerber Lauren J, Pellegrini Cecilia, Wang Hanbin, Fenner Maria, Tse Stephanie, Marks Adam, Nchako Corbyn, Brivanlou Ali H

Abstract excerpt

Huntington's disease (HD) is a fatal neurodegenerative disease caused by expansion of CAG repeats in the Huntingtin gene (HTT). Neither its pathogenic mechanisms nor the normal functions of HTT are well understood. To model HD in humans, we engineered a genetic allelic series of isogenic human embryonic stem cell (hESC) lines with graded increases in CAG repeat length. Neural differentiation of these lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29378824
DOI: 10.1242/dev.156844

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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